3-(3-Fluorophenyl)-2-propenoic acid → 3-(3-Fluorophenyl)propionic acid

HRID 1844045

Reaction equation

HRID 1844045 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 886063-(3-Fluorophenyl)-2-propenoic acid

Product 1

HCID 27374893-(3-Fluorophenyl)propionic acidYield 80.69%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(3-Fluorophenyl)acrylic acid (I-78a: 6.4 gm, 38.5 mmol) in methanol (100 mL) was reduced with 10% Pd/C (640 mg) to afford the crude product, 5 g (80.69% yield).

Sources & evidence

ORD record
ord-7a510fce0be64052bf67aa17848ce7a5
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Linked notes

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