Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride

HRID 1844372

Reaction equation

HRID 1844372 reaction equation
[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[C:8]([F:14])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:17])=O>>[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[C:8]([F:14])=[CH:7][C:3]=1[C:4]([Cl:17])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27339702,4,5-Trifluoro-3-methoxybenzoic acid

Product 1

HCID 27752812,4,5-Trifluoro-3-methoxybenzoyl chloride

Procedure

A mixture of 2,4,5-trifluoro-3-methoxybenzoic acid (154 mg, 0.75 mmol) and thionyl chloride (8 mL) is refluxed for 4 h. Excess thionyl chloride is removed in vacuo, and the remaining residue is used directly in the next synthetic step.

Workup

  1. temperatureis refluxed for 4 h
  2. customExcess thionyl chloride is removed in vacuo

Sources & evidence

ORD record
ord-d8bd22cc7a604f0ea2f8c25d160b063b
Source dataset
uspto-grants-2015_02
Patent number
US08946422B2

Linked notes

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