N*2*,N*2*-Dimethyl-[1,2,4]triazolo[1,5-a]pyridine-2,6-diamine → 5-(2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 1844461

Reaction equation

HRID 1844461 reaction equation
CN(C)C1N=C2C=CC(N)=CN2N=1.[CH2:14]([O:16][C:17]([C:19]1[CH:20]=[N:21][N:22]([CH3:42])[C:23]=1[C:24](=[O:41])[NH:25][C:26]1[CH:27]=[CH:28][C:29]2[N:30]([N:32]=[C:33]([N:35]3[CH2:40]COC[CH2:36]3)[N:34]=2)[CH:31]=1)=[O:18])[CH3:15]>>[CH2:14]([O:16][C:17]([C:19]1[CH:20]=[N:21][N:22]([CH3:42])[C:23]=1[C:24](=[O:41])[NH:25][C:26]1[CH:27]=[CH:28][C:29]2[N:30]([N:32]=[C:33]([N:35]([CH3:36])[CH3:40])[N:34]=2)[CH:31]=1)=[O:18])[CH3:15]

Participants

3

Reactant 2

HCID 89463594N*2*,N*2*-Dimethyl-[1,2,4]triazolo[1,5-a]pyridine-2,6-diamineHCID 894647211-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 894638695-(2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Procedure

Using N*2*,N*2*-dimethyl-[1,2,4]triazolo[1,5-a]pyridine-2,6-diamine, this compound was prepared following the same method as for the synthesis of 1-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester. White solid (64 mg, 48%). Mp.: 194° C. MS: m/z=358 (M+H+).

Workup

  1. customthis compound was prepared

Sources & evidence

ORD record
ord-fb25f185ec014fbd98997cb6ecf764c2
Source dataset
uspto-grants-2015_02
Patent number
US08946427B2

Linked notes

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