Acetic Acid → 2,7-dimethyl-3H-benzimidazol-5-ol

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=1[NH2:8].[C:11](O)(=O)[CH3:12]>>[CH3:11][C:12]1[NH:1][C:2]2[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=2[N:8]=1

Participants

Reactant 2

HCID 176Acetic Acid

HCID 199076443,4-Diamino-5-methylphenol

Product 1

HCID 669782362,7-dimethyl-3H-benzimidazol-5-ol

Procedure

0.553 g (4.00 mml) 3,4-diamino-5-methyl-phenol in 5.00 mL glacial acetic acid were boiled for 3 h. Then the reaction mixture was evaporated down and dried under HV.

Workup

customThen the reaction mixture was evaporated down
customdried under HV

Sources & evidence

ORD record: ord-78ab22a252eb429682514ead839f265e
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08952014B2

Reaction notes

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