(1R,3R)-3-Aminocyclohexane-1-carboxylic acid 2,2,2-trifluoroacetic acid salt → ((1R,3R)-3-Aminocyclohexyl)methanol

HRID 1848225Notes

Reaction equation

HRID 1848225 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][C@@H:11]([C:15](O)=[O:16])[CH2:10]1.Cl.N[C@H]1CC[C@H](C(O)=O)CC1>>[NH2:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][C@@H:11]([CH2:15][OH:16])[CH2:10]1

Participants

3

Reactant 2

HCID 86681198(1R,3R)-3-Aminocyclohexane-1-carboxylic acid 2,2,2-trifluoroacetic acid saltHCID 178479263HCID 178479263, compound

Product 1

HCID 55284699((1R,3R)-3-Aminocyclohexyl)methanol

Procedure

((1R,3R)-3-Aminocyclohexyl)methanol was synthesized as a white powder (213 mg, 75%) using a procedure analogous to that described in Step 1 of Example 179, substituting (1R,3R)-3-aminocyclohexanecarboxylic acid trifluoroacetate from the previous step for trans-4-aminocyclohexanecarboxylic acid hydrochloride used in Example 179.

Sources & evidence

ORD record
ord-9071586c0a234dc1aca2ff05541e819d
Source dataset
uspto-grants-2015_02
Patent number
US08952058B2

Reaction notes

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