Hydrochloride methanol → [1-(3-Azetidin-3-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochloride

Reaction equation

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[NH:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58547227HCID 58547227, compound

Product 1

HCID 67469292[1-(3-Azetidin-3-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochlorideYield 98%

Procedure

A solution of (36) (557 mg, 1.6 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give (37) (450 mg, 1.58 mmol, yield 98%).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-b6cc3478763440b485420695ef72acb5
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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