Pyridine → 4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester

Reaction equation

[CH3:14][O:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][c:21]2[c:22]([cH:27]1)[NH:23][CH2:24][CH2:25][O:26]2.[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:12][CH3:13])[c:6]([S:8](=[O:9])(=[O:10])[Cl:11])[cH:7]1.[Cl:28][CH2:29][Cl:30].[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:12][CH3:13])[c:6]([S:8](=[O:9])(=[O:10])[N:23]2[c:22]3[c:21]([cH:20][cH:19][c:18]([C:16]([O:15][CH3:14])=[O:17])[cH:27]3)[O:26][CH2:25][CH2:24]2)[cH:7]1

Participants

Reactant 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 27342725-Chloro-2-methoxybenzene-1-sulfonyl chloride

HCID 16244461methyl 3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

Product 1

HCID 667888284-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester

Sources & evidence

ORD record: ord-9cc55fe879ed47e8bc8f004b17014e76
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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