Water → 4-(4-Nitrophenyl)morpholine

HRID 18524

Reaction equation

HRID 18524 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.F[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.O>CS(C)=O>[N+:14]([C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:9][CH:10]=1)([O-:16])=[O:15]

Participants

5

Reactant 3

HCID 962WaterHCID 8083MorpholineHCID 9590p-Fluoronitrobenzene

Product 1

HCID 252224-(4-Nitrophenyl)morpholine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 24.5 g morpholine and 13.3 g 1-Fluoro-4-nitro-benzene in 30 mL DMSO was heated to 100° C. for 4 h. This solution was poured on to 300 mL of water and the resulting precipitate was collected by filtration to yield a bright yellow crystalline product, which was dried under reduced pressure. Yield: 19.7 g.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. customto yield a bright yellow crystalline product, which
  3. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-7ec65ea9668e4169bf4f2fb65aa3f539
Source dataset
uspto-grants-2010_06
Patent number
US07741341B2

Linked notes

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