Sodium Hydroxide → 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid
Reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([O:15]CC)=[O:14])[CH:3]=1.[OH-].[Na+]>CCO>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([OH:15])=[O:14])[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2 g (8.65 mmol) of ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate are dissolved in 20 ml EtOH and 20 ml of 1M NaOH solution are added. The mixture is stirred overnight, the solvent removed in vacuo and the crude product subject to HPLC chromatography: Yield: 65%
Workup
- customthe solvent removed in vacuo
Sources & evidence
- ORD record
- ord-b72cc373c3ff4338887adf24861b0448
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08962671B2
Reaction notes
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