3-fluoro-4-(2-methyl-1H-imidazol-1-yl)aniline → (4-Benzyl-6-methyl-pyrimidin-2-yl)-[3-fluoro-4-(2-methyl-imidazol-1-yl)-phenyl]-amine
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:14])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH3:13].[CH2:15]([C:22]1[CH:27]=[C:26]([CH3:28])[N:25]=[C:24](Cl)[N:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([C:22]1[CH:27]=[C:26]([CH3:28])[N:25]=[C:24]([NH:14][C:4]2[CH:5]=[CH:6][C:7]([N:8]3[CH:12]=[CH:11][N:10]=[C:9]3[CH3:13])=[C:2]([F:1])[CH:3]=2)[N:23]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1Participants
3
Procedure
The title compound was prepared from 3-fluoro-4-(2-methyl-imidazol-1-yl)-phenylamine (87 mg, 0.46 mmol) and 4-benzyl-2-chloro-6-methyl-pyrimidine (100 mg, 0.46 mmol) in analogous manner to the procedure described in example 1e). Obtained as a light yellow oil (140 mg, 82%).
Sources & evidence
- ORD record
- ord-ceede4dd4ae14ee4a70b3f5f44c8015a
- Source dataset
- uspto-grants-2015_02
- DOI