tert-Butoxy bis(dimethylamino)methane → HCID 68632008, compound

Reaction equation

[CH3:1][C:2]1[N:6]=[C:5]([CH2:7][C:8](=[O:10])[CH3:9])[O:4][N:3]=1.C(O[CH:16](N(C)C)[N:17]([CH3:19])[CH3:18])(C)(C)C>>[CH3:16][N:17]([CH3:19])[CH:18]=[C:7]([C:5]1[O:4][N:3]=[C:2]([CH3:1])[N:6]=1)[C:8](=[O:10])[CH3:9]

Participants

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methane

HCID 129553831-(3-Methyl-1,2,4-oxadiazol-5-yl)acetone

Product 1

HCID 68632008HCID 68632008, compound

Procedure

1-(3-Methyl-[1,2,4]oxadiazol-5-yl)-propan-2-one (224 mg, 1.6 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 28a) to give crude title compound (313 mg) as a yellow oil which was used directly in the next step.

Sources & evidence

ORD record: ord-6d7dc51192914be8a9db0cd507fa96fe
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962834B2

Reaction notes

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