Benzoyl chloride → 2-benzoyl-1H-imidazole

HRID 1858118Notes

Reaction equation

[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[C:11]1[NH:12][CH:13]=[CH:14][N:15]=1>>[C:1]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 127492-Methylimidazole

Product 1

HCID 1861972-benzoyl-1H-imidazoleYield 60%

Procedure

Benzoyl imidazole was prepared by the above procedure using benzoyl chloride (28.1 grams, 200 mmole) and 2-methylimidazole (16.4 grams, 210 mmole), in an amount of 22.4 grams (60% yield).

Sources & evidence

ORD record: ord-61f9e9b7b665447a8448edfa9b779967
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06150479

Reaction notes

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