2-Chloro-5-(chloromethyl)pyridine → 2-Chloro-5-methyl-pyridine

HRID 1858164Notes

Reaction equation

HRID 1858164 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:9])=[N:7][CH:8]=1.[Cl:10][CH:11]([Cl:19])[C:12]1[CH:13]=[CH:14][C:15]([Cl:18])=[N:16][CH:17]=1>>[Cl:10][CH:11]([Cl:19])[C:12]1[CH:13]=[CH:14][C:15]([Cl:18])=[N:16][CH:17]=1.[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:9])=[N:7][CH:8]=1

Participants

4

Reactant 2

HCID 1554792-Chloro-5-(chloromethyl)pyridine2×HCID 5948792-Chloro-5-(dichloromethyl)pyridine

Product 2

HCID 5813932-Chloro-5-methyl-pyridineHCID 5948792-Chloro-5-(dichloromethyl)pyridine

Procedure

The present invention relates to the preparation of 5-aminomethyl-2-chloropyridines by reacting a mixture of 5-chloromethyl-2-chloropyridine and 5-dichloromethyl-2-chloropyridine with substituted amines. The mixture of 5-chloromethyl-2-chloropyridine and 5-dichloromethyl-2-chloropyridine is obtained by chlorination of the 5-methyl-2-chloropyridine.

Sources & evidence

ORD record
ord-4301720d52e74943a1cfc51b7a973ca3
Source dataset
uspto-grants-2000_11
Patent number
US06150528

Reaction notes

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