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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1858554Generated: October 27, 2026

2-Bromomethylnaphthalene → tert-butyl (3RS,4RS)-4-(4-bromophenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

https://huagongshe.com/reaction/1858554

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-BromomethylnaphthaleneHCID 70320—
Reactanttert-butyl (3RS,4RS)-4-(4-bromophenyl)-3-hydroxy-piperidine-1-carboxylateHCID 54537313—
Producttert-butyl (3RS,4RS)-4-(4-bromophenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylateHCID 54500256—

Reaction Steps

By alkylating tert-butyl (3RS,4RS)-4-(4-bromophenyl)-3-hydroxy-piperidine-1-carboxylate with 2-bromomethyl-naphthalene there was obtained tert-butyl (3RS,4RS)-4-(4-bromophenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a colourless solid; MS: 495, 497 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06150526
Source datasetuspto-grants-2000_11
ORD IDord-1b67c7593d3347debee9756127cf7744
Source noteuspto-grants-2000_11