1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine → 1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(2,5-diiodophenyl)methyl]piperazine
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH2:15][CH2:14][CH:13]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)[CH2:12][CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.[I:22][C:23]1[CH:30]=[CH:29][C:28]([I:31])=[CH:27][C:24]=1[CH2:25]Cl>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH2:15][CH2:14][CH:13]([N:16]4[CH2:21][CH2:20][N:19]([CH2:25][C:24]5[CH:27]=[C:28]([I:31])[CH:29]=[CH:30][C:23]=5[I:22])[CH2:18][CH2:17]4)[CH2:12][CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1Participants
3
Procedure
The title compound was prepared from 1-[4-(1,3-benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine (0.25 g, 0.87 mmole) and 2,5-diiodobenzyl chloride (0.33 g, 0.87 mmole) by the method described in example 45 to give the product (82%, mp: 174-175° C.). Calc'd for C24H26I2N2O2 : C, 45.89%; H, 4.18%; N, 4.46%. Found: C, 45.58%; H, 4.13%; N, 4.35%.
Sources & evidence
- ORD record
- ord-191813b9f1b44e1d8bb84e30ae54863b
- Source dataset