Methyl 4-(3-formylphenyl)benzoate → HCID 18626005, compound
Reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1)=[O:2].[CH:19]([O-])([O-])[O:20]C.F[C:25](F)(C(F)F)COC1C=CC(C(NCCOC2C=CC(CC(OC3C=CC(C(C)C)=CC=3)C(O)=O)=CC=2)=O)=CN=1>>[CH3:25][O:2][CH:1]([O:20][CH3:19])[C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1Participants
4
Procedure
In a similar manner to that described in Example 11(a), a reaction was carried out using methyl 3′-formylbiphenyl-4-carboxylate (1.60 g), which is the product of Reference example 14(a), methyl orthoformate (3.64 ml) and amberlyst 15 (160 mg) and the reaction mixture was treated to afford the desired compound (1.91 g) as a syrup.
Workup
- addition