Sodium Hydroxide → Sodium 2-butyl-3-[4-[2-(3'-methoxymethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate
Reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([CH2:36][O:37][CH2:38][O:39][CH3:40])[CH:31]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+:42]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([CH2:36][O:37][CH2:38][O:39][CH3:40])[CH:31]=3)=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([O-:8])=[O:7])[CH2:2][CH2:3][CH3:4].[Na+:42]Participants
3
Procedure
In a similar manner to that described in Example 2, a reaction was carried out using ethyl 2-butyl-3-[4-[2-(3′-methoxymethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (573 mg), which is the product of Reference example 15(d), and aqueous sodium hydroxide (1N, 2.00 ml) and the reaction mixture was treated to afford the desired compound (472 mg) as a white powder.