Sodium Hydroxide → 3-[4-[2-(4'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionic acid
Reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH:31]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]([O:34]CC)=[O:33])=[CH:26][CH:25]=3)=[O:19])=[CH:14][CH:13]=2)=[CH:7][C:6]=1[CH3:44].[OH-].[Na+]>>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH:31]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]([OH:34])=[O:33])=[CH:26][CH:25]=3)=[O:19])=[CH:16][CH:17]=2)=[CH:7][C:6]=1[CH3:44]Participants
3
Procedure
In a similar manner to that described in Example 2, a reaction was carried out using ethyl 3-[4-[2-(4′-methoxymethoxy-3′,5′-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (720 mg), which is the product of Reference example 24(a) and aqueous sodium hydroxide (1N, 2.40 ml) and the reaction mixture was treated to afford the title compound (520 mg) as a white powder.