Sodium Hydroxide → 6-(4-Methoxyphenyl)nicotinic acid

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625729HCID 18625729, compound

Product 1

HCID 186259336-(4-Methoxyphenyl)nicotinic acidYield 70.7%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-methoxyphenyl)nicotinate (3.95 g) and aqueous sodium hydroxide solution (1N, 32.5 ml) and the reaction mixture was treated to afford the title compound (2.63 g) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-e70ca072ff05452e8dda5e203b16360c
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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