Sodium Hydroxide → 2-(5-(Trifluoromethyl)pyridin-2-yl)benzoic acid

HRID 1860052

Reaction equation

HRID 1860052 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([O:13]C)=[O:12])=[CH:7][CH:8]=1.[OH-].[Na+]>>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([OH:13])=[O:12])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625897Methyl 3-trifluoromethylpyridine-6-ylbenzoate

Product 1

HCID 227369092-(5-(Trifluoromethyl)pyridin-2-yl)benzoic acidYield 72.7%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3-trifluoromethylpyridine-6-ylbenzoate (791 mg) and aqueous sodium hydroxide solution (1N, 5.60 ml) and the reaction mixture was treated to afford the title compound (546 mg) which includes some impurity and was used in example 106 without further purification.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-c54feab767b34f7c8e3d3a9cfdd867f1
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Linked notes

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