2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbaldehyde → 3-(2,2-Dimethylchroman-6-ylmethylene)-5-fluoro-1,3-dihydroindol-2-one

HRID 1860775

Reaction equation

HRID 1860775 reaction equation
[CH3:1][C:2]1([CH3:14])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:12]=O)[CH:8]=2)[O:3]1.[F:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[CH2:19]2>>[CH3:1][C:2]1([CH3:14])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:12]=[C:19]3[C:18]4[C:22](=[CH:23][CH:24]=[C:16]([F:15])[CH:17]=4)[NH:21][C:20]3=[O:25])[CH:8]=2)[O:3]1

Participants

3

Reactant 2

HCID 17977512,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbaldehydeHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 544054613-(2,2-Dimethylchroman-6-ylmethylene)-5-fluoro-1,3-dihydroindol-2-one

Procedure

2,2-Dimethyl-6-formylchromane (commercially available) was condensed with 5-fluoro-2-oxindole to give 0.3 g of 3-(2,2-Dimethylchroman-6-ylmethylene)-5-fluoro-1,3-dihydroindol-2-one as a yellow-orange solid.

Sources & evidence

ORD record
ord-f3ff5ee87ca440b49ff29d759d8ebcce
Source dataset
uspto-grants-2003_03
Patent number
US06531502B1

Linked notes

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