Acetyl chloride → Hydroxyethylidenediphosphonic acid

HRID 1861597

Reaction equation

HRID 1861597 reaction equation
[P:1]([O:12][Si](C)(C)C)([O:7][Si](C)(C)C)[O:2][Si](C)(C)C.[C:17](Cl)(=[O:19])[CH3:18]>CO>[OH:19][CH2:17][CH:18]([P:1](=[O:2])([OH:12])[OH:7])[P:1](=[O:12])([OH:7])[OH:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 137213Tris(trimethylsilyl) phosphite

Product 1

HCID 9977539Hydroxyethylidenediphosphonic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Tris(trimethylsilyl) phosphite (2 molar equiv.) in an appropriate dry solvent was added dropwise to a stirred solution of acetyl chloride (1 molar equiv.) in an appropriate dry solvent at room temperature and the mixture stirred for 10 minutes. Excess methanol was then added and the mixture stirred for 5 minutes to decompose the silyl esters. The volatile components in the reaction mixture were then removed under reduced pressure to leave the title compound in good purity.

Workup

  1. stirringthe mixture stirred for 5 minutes
  2. customThe volatile components in the reaction mixture were then removed under reduced pressure

Sources & evidence

ORD record
ord-f82e89ad44eb4d42a5e41a178cb7c5fd
Source dataset
uspto-grants-2003_03
Patent number
US06534488B1

Linked notes

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