N-Methyl-N'-nitro-N-nitrosoguanidine → HCID 178512011, compound

Reaction equation

[N+:1]([N:4]=[C:5]([NH2:15])[NH:6][C:7]1[CH:8]=[C:9]([CH2:13][NH2:14])[CH:10]=[CH:11][CH:12]=1)([O-:3])=[O:2].C[N:17](N=O)[C:18]([NH:20][N+:21]([O-:23])=[O:22])=N>>[N+:21]([N:20]=[C:18]([NH2:17])[NH:14][CH2:13][C:9]1[CH:8]=[C:7]([NH:6][C:5]([NH:4][N+:1]([O-:3])=[O:2])=[NH:15])[CH:12]=[CH:11][CH:10]=1)([O-:23])=[O:22]

Participants

Reactant 2

HCID 135436526N-Methyl-N'-nitro-N-nitrosoguanidine

HCID 136388334HCID 136388334, compound

Product 1

HCID 178512011HCID 178512011, compoundYield 25%

Procedure

Using the compound obtained in Example 34 as a starting material and also using N-methyl-N′-nitro-N-nitrosoguanidine as a reagent, reaction was performed as in Example 83 to give the titled compound (yield, 25%).

Workup

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Sources & evidence

ORD record: ord-53b40aae7a714a5b96d18b3931761ca7
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06534546B1

Reaction notes

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