Sucralose 6-acetate → (2R,3S,4R,5R,6S)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol

A mixture of 20 g of dry sucralose-6-acetate obtained from Example 5 and 70 ml of methanol was heated to from 40° C. to 50° C. When the reacting mixture became a clear solution, a small quantity of a 30% sodium methylate solution was added. After the mixture was stirred for 2 hours, methanol was removed under reduced pressure. The resultant mixture was diluted to a 30% mixture by adding a certain quantity of water, which was decolored and then filtered. The filtrate thus obtained was concentrated to a 65% solution, which was cooled to form crystallized sucralose. The obtained crystal was filtered and dried to give sucralose with a yield of over 95% and purity of over 98.0%.

1. temperaturewas heated to from 40° C. to 50° C
2. custommethanol was removed under reduced pressure
3. additionThe resultant mixture was diluted to a 30% mixture
4. additionby adding a certain quantity of water, which
5. filtrationfiltered
6. customThe filtrate thus obtained
7. concentrationwas concentrated to a 65% solution, which
8. temperaturewas cooled
9. customto form
10. customcrystallized sucralose
11. filtrationThe obtained crystal was filtered
12. customdried

ORD record

ord-89542098a95b4599bac600c077c6b4da

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07626016B2