4-Morpholinecarbonyl chloride → 5-[(1,1-Dimethyl)ethyl]-2-[(morpholinocarbonyl)oxy]-N-[3,5-bis(trifluoromethyl)-phenyl]benzamide
Reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[CH:7][C:8]([OH:28])=[C:9]([CH:27]=1)[C:10]([NH:12][C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[C:15]([C:23]([F:26])([F:25])[F:24])[CH:14]=1)=[O:11])([CH3:4])[CH3:3].[N:29]1([C:35](Cl)=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[CH3:4][C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:28][C:35]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[O:36])=[C:9]([CH:27]=1)[C:10]([NH:12][C:13]1[CH:14]=[C:15]([C:23]([F:26])([F:24])[F:25])[CH:16]=[C:17]([C:19]([F:20])([F:21])[F:22])[CH:18]=1)=[O:11])([CH3:1])[CH3:3]Participants
3
Procedure
Using 5-[(1,1-dimethyl)ethyl]-2-hydroxy-N-[3,5-bis(trifluoromethyl)-phenyl]benzamide and morpholine-4-carbonyl chloride as the raw materials, the same operation as the Example 71 gave the title compound.
Sources & evidence
- ORD record
- ord-0a6745db9aeb47c5b6ef4054be83d0ef