1-Benzyl-4-(methylamino)piperidine-4-carboxamide → 4-(Methylamino)piperidine-4-carboxamide
Reaction equation
C([N:4]1[CH2:9][CH2:8][C:7]([NH:13][CH3:14])([C:10]([NH2:12])=[O:11])[CH2:6][CH2:5]1)(C)C.C(N1CCC(NC)(C(N)=O)CC1)C1C=CC=CC=1>>[CH3:14][NH:13][C:7]1([C:10]([NH2:12])=[O:11])[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1Participants
3
Procedure
The 1-isopropyl-4-(methylamino)piperidine-4-carboxamide used as starting material was prepared as follows: 1-benzyl-4-(methylamino)piperidine-4-carboxamide (J Med Chem., 1998, 41(25), 5084) may be deprotected by hydrogenation using an analogous method to that described for the equivalent step in Example 74 to give 4-(methylamino)piperidine-4-carboxamide; 1H NMR Spectrum: 1.35 (m, 2H); 1.68 (m, 2H); 1.93 (brs, 1H); 2.06 (s, 3H), 2.59 (m, 2H); 2.71 (m, 2H); 6.81 (s, 1H); 7.14 (s, 1H).
Workup
- customwas prepared