Thionyl Chloride → 2-(3-Chlorophenyl)-2-methylpropanoyl chloride

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:13])([CH3:12])[C:9]([Cl:16])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 155826442-(3-Chlorophenyl)-2-methylpropanoic acid

Product 1

HCID 139875312-(3-Chlorophenyl)-2-methylpropanoyl chloride

Procedure

2-(3-Chlorophenyl)-2-methylpropanoic acid (5.7 g, 28.7 mmol) was stirred in thionyl chloride (100 mL) for 2 hours at reflux. The thionyl chloride was removed under vacuum to give the product (5.69 g).

Workup

temperatureat reflux
customThe thionyl chloride was removed under vacuum

Sources & evidence

ORD record: ord-c312d124c2c746a6b07cdf605b776d85
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07635715B2

Reaction notes

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