4-Amino-2-(trifluoromethyl)benzonitrile → 1,1,1-Trifluoro-4-phenyl-2-[(4-cyano-3-(trifluoromethyl)phenyl)iminomethyl]-4-methylpentan-2-ol

HRID 1869360

Reaction equation

HRID 1869360 reaction equation
[OH:1][C:2]([C:15]([F:18])([F:17])[F:16])([CH2:5][C:6]([CH3:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[CH:3]=O.[C:19]([C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][C:22]=1[C:28]([F:31])([F:30])[F:29])#[N:20]>>[F:16][C:15]([F:18])([F:17])[C:2]([CH:3]=[N:25][C:24]1[CH:26]=[CH:27][C:21]([C:19]#[N:20])=[C:22]([C:28]([F:29])([F:30])[F:31])[CH:23]=1)([OH:1])[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:14])[CH3:7]

Participants

3

Reactant 2

HCID 5221704-Amino-2-(trifluoromethyl)benzonitrileHCID 179890922-Hydroxy-4-methyl-4-phenyl-2-trifluoromethylpentanal

Product 1

HCID 179891761,1,1-Trifluoro-4-phenyl-2-[(4-cyano-3-(trifluoromethyl)phenyl)iminomethyl]-4-methylpentan-2-ol

Procedure

Analogously to Example 13, 120 mg of 2-hydroxy-4-methyl-4-phenyl-2-(trifluoromethyl)pentanal and 78 mg of 4-cyano-3-(trifluoromethyl)aniline are converted into 71 mg of product.

Sources & evidence

ORD record
ord-a1976d7aafd44465b8a472d78d276dc6
Source dataset
uspto-grants-2009_12
Patent number
US07638515B2

Linked notes

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