3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-benzaldehyde → 5-[3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-phenyl]-penta-2,4-dienoic acid

HRID 1869550

Reaction equation

HRID 1869550 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:26])=[C:10]([C:13]3[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=3[O:21][C:22]([F:25])([F:24])[F:23])C=O)[CH:11]=2)[C:6]([CH3:28])([CH3:27])[CH2:5][C:4]1=[O:29])[CH3:2].[CH2:30]([CH:32](P(O)(O)=O)/[C:33](/CC)=[C:34](\CC)/[C:35]([O-:37])=[O:36])C>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:26])=[C:10]([C:13]3[CH:14]=[C:15]([CH:30]=[CH:32][CH:33]=[CH:34][C:35]([OH:37])=[O:36])[CH:18]=[CH:19][C:20]=3[O:21][C:22]([F:24])([F:25])[F:23])[CH:11]=2)[C:6]([CH3:28])([CH3:27])[CH2:5][C:4]1=[O:29])[CH3:2]

Participants

3

Reactant 2

HCID 112234493-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-benzaldehydeHCID 86585716(E)-2,3-diethyl-4-phosphonohex-2-enoate

Product 1

HCID 766968335-[3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-phenyl]-penta-2,4-dienoic acid

Procedure

Compound 24 was prepared from Compound 2A using procedures similar to those described for Example 20B and 20C, except using triethyl-4-phosphonocrotonate in step 20B. MS (electrospray): mass calculated for C26H26F3NO4, 473.18; m/z found 474.2 [M+H]+.

Sources & evidence

ORD record
ord-90df589969f8493183119a984d2796a3
Source dataset
uspto-grants-2009_12
Patent number
US07638533B2

Linked notes

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