2-(Morpholin-4-yl)ethane-1-sulfonamide → N-(2-(Morpholino)ethanesulphonyl)-6-[N-(5-chloro-2-(2-methylprop-2-en-1-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide

HRID 1870746

Reaction equation

HRID 1870746 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH2:22][C:23]([CH3:25])=[CH2:24])=[C:6]([CH:20]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]([OH:19])=O)=[CH:13][CH:12]=1)[CH2:9][CH3:10].[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][S:34]([NH2:37])(=[O:36])=[O:35])[CH2:28][CH2:27]1>>[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][S:34]([NH:37][C:17]([C:14]2[N:15]=[N:16][C:11]([N:8]([CH2:7][C:6]3[CH:20]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:21][CH2:22][C:23]([CH3:25])=[CH2:24])[CH2:9][CH3:10])=[CH:12][CH:13]=2)=[O:19])(=[O:36])=[O:35])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 124698162-(Morpholin-4-yl)ethane-1-sulfonamideHCID 186932496-[N-(5-Chloro-2-(2-methylprop-2-en-1-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic acid

Product 1

HCID 18693229N-(2-(Morpholino)ethanesulphonyl)-6-[N-(5-chloro-2-(2-methylprop-2-en-1-yloxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide

Procedure

The title compound was prepared by reacting 6-[N-(5-chloro-2-(2-methylprop-2-enyloxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic acid (example 19) and 2-(morpholino)ethanesulphonamide using a similar method to that described in example 20 (yield 43%).

Sources & evidence

ORD record
ord-65b49cecad3946bca411afd999ab13db
Source dataset
uspto-grants-2000_08
Patent number
US06100258

Linked notes

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