Toluene → 7-Acetyl-1'-methyl-2,3,5,6-tetrahydrospiro[furo[3,2-f]indole-3,4'-piperidine]
Reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9](Br)=[C:10]([O:13][CH2:14][C:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH:16]=3)[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C1(C)C=CC=CC=1>C1C=CC=CC=1>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]3[C:15]4([CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]4)[CH2:14][O:13][C:10]=3[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]Participants
4
Procedure
The title compound was prepared from 1-acetyl-5-bromo-6-[(1-methyl-1,2,5,6-tetrahydropyridine-4-yl)methoxy]indoline (D65) using a similar procedure to Description 8b in WO96/19477, but with toluene at 80° C. in place of refluxing benzene. The product was obtained from the acid/base purification as a beige solid (94%).