cis-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one → (cis)-4-(3,4-Dimethoxyphenyl)-2-cyclooctyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH:22]1(NN)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH:22]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]Participants
3
Procedure
Prepared from compound 3 and cyclooctylhydrazine as described for compound 35. Purified by chromatography (dichloromethane) and crystallized from petroleum ether (40-60° C.). M.p. 75-77° C.
Workup
- customPurified by chromatography (dichloromethane)
- customcrystallized from petroleum ether (40-60° C.)