Water → 1-(Bromomethyl)-3-ethylbenzene
Reaction equation
P(Br)(Br)[Br:2].[CH2:5]([C:7]1[CH:8]=[C:9]([CH2:13]O)[CH:10]=[CH:11][CH:12]=1)[CH3:6].O>C1C=CC=CC=1>[Br:2][CH2:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([CH2:5][CH3:6])[CH:8]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Phosphorous tribromide (5.3 ml) was added to a solution of the product from step (i) (7.6 g) in benzene (150 ml) at 0° C. After 3 hours, water (40 ml) was added and the mixture warmed to room temperature and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 2% ethyl acetate in isohexane. Yield 8.0 g.
Workup
- extractionextracted with ethyl acetate
- dry with materialThe organic phase was dried (MgSO4)
- customevaporated
- customPurified by chromatography
- washeluting with 2% ethyl acetate in isohexane
Sources & evidence
- ORD record
- ord-b501f9e1eb8544469e9e0de14223e35f
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06107297
Reaction notes
Loading…