((1S)-1-Methylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester → HCID 13689669, compound

Reaction equation

C(OC(=O)[NH:7][C@H:8]([C:16](=[O:19])[NH:17][CH3:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.[ClH:21].O1CCOCC1>>[ClH:21].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]([NH:17][CH3:18])=[O:19]

Participants

Reactant 2

HCID 7201346((1S)-1-Methylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

HCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 13689669HCID 13689669, compound

Procedure

[((1S)-1-Methylcarbamoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (2.35 g, 8.45 mmol) was dissolved in 4 M HCl-dioxane (20 ml) at 25° C. for 2 hours. The mixture was concentrated and the residue triturated with ether, and dried. Yield 1.70 g, 94%.

Workup

concentrationThe mixture was concentrated
customthe residue triturated with ether
customdried

Sources & evidence

ORD record: ord-a9043e1d71734bc98d3ba01b97249a94
Source dataset: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06107329

Reaction notes

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