Methanol → 3-[[2-[3-[4-(4-Chloro-3-fluorophenyl)piperidin-1-yl]-2-hydroxypropoxy]phenyl]methylidene]oxolan-2-one

HRID 187255

Reaction equation

HRID 187255 reaction equation
[CH3:33][OH:34].[Cl:19][c:20]1[c:21]([F:32])[cH:22][c:23]([CH:26]2[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2)[cH:24][cH:25]1.[O:1]1[CH:2]([CH2:3][O:4][c:5]2[c:6]([CH:7]=[C:8]3[C:9](=[O:10])[O:11][CH2:12][CH2:13]3)[cH:14][cH:15][cH:16][cH:17]2)[CH2:18]1>>[OH:1][CH:2]([CH2:3][O:4][c:5]1[c:6]([CH:7]=[C:8]2[C:9](=[O:10])[O:11][CH2:12][CH2:13]2)[cH:14][cH:15][cH:16][cH:17]1)[CH2:18][N:29]1[CH2:28][CH2:27][CH:26]([c:23]2[cH:22][c:21]([F:32])[c:20]([Cl:19])[cH:25][cH:24]2)[CH2:31][CH2:30]1

Participants

4

Reactant 3

HCID 887MethanolHCID 166793134-(4-Chloro-3-fluorophenyl)piperidineHCID 72642278alpha-(2'-(2,3-Epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone

Product 1

HCID 694978083-[[2-[3-[4-(4-Chloro-3-fluorophenyl)piperidin-1-yl]-2-hydroxypropoxy]phenyl]methylidene]oxolan-2-one

Sources & evidence

ORD record
ord-849bf4ea652942fbacdb5b163210c709
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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