Piperazin-2-one → 4-{3-[5-(2-Fluoro-phenyl)-thiophen-2-yl]-acryloyl}-piperazin-2-one

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:12][C:11]([CH:13]=[CH:14][C:15]([OH:17])=O)=[CH:10][CH:9]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][C:19]1=[O:24]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:12][C:11]([CH:13]=[CH:14][C:15]([N:21]2[CH2:22][CH2:23][NH:18][C:19](=[O:24])[CH2:20]2)=[O:17])=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 231360Piperazin-2-one

HCID 53412006HCID 53412006, compound

Product 1

HCID 685379594-{3-[5-(2-Fluoro-phenyl)-thiophen-2-yl]-acryloyl}-piperazin-2-one

Procedure

The compound was prepared analogously to Example 4(b) using 150 mg (0.6 mmol) of 3-[5-(2-fluoro-phenyl)-thiophen-2-yl]-acrylic acid and 54.2 mg (0.54 mmol) of piperazin-2-one. Yield: 109 mg.

Workup

customThe compound was prepared analogously to Example 4(b)

Sources & evidence

ORD record: ord-69788ef9ea864ee8b837e43bea7dcfd1
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08304438B2

Reaction notes

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