3-(Bromomethyl)-3-fluorooxetane → 1'-({6-Chloro-1-[(3-fluorooxetan-3-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 187444

Reaction equation

HRID 187444 reaction equation
[Br:28][CH2:29][C:30]1([F:34])[CH2:31][O:32][CH2:33]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][C:18](=[O:25])[c:19]5[c:20]4[cH:21][cH:22][cH:23][cH:24]5)[CH2:26][CH2:27]3)[cH:7][nH:8][c:9]2[cH:10]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][C:18](=[O:25])[c:19]5[c:20]4[cH:21][cH:22][cH:23][cH:24]5)[CH2:26][CH2:27]3)[cH:7][n:8]([CH2:29][C:30]3([F:34])[CH2:31][O:32][CH2:33]3)[c:9]2[cH:10]1

Participants

3

Reactant 2

HCID 221608003-(Bromomethyl)-3-fluorooxetaneHCID 596575991'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 596577101'-({6-Chloro-1-[(3-fluorooxetan-3-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Sources & evidence

ORD record
ord-8c1155884e53466e99e47f557548d227
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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