Methyl iodide → 5,6-Dimethyl-4,5-dihydro-thieno[2,3-c]pyridinium iodide
Reaction equation
[CH3:1][CH:2]1[N:7]=[CH:6][C:5]2[S:8][CH:9]=[CH:10][C:4]=2[CH2:3]1.[CH3:11][I:12]>C(#N)C>[I-:12].[CH3:1][CH:2]1[N+:7]([CH3:11])=[CH:6][C:5]2[S:8][CH:9]=[CH:10][C:4]=2[CH2:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4.0 g (26.5 mmol) 5-methyl-4,5-dihydro-thieno[2,3-c]-pyridine in 250 ml acetonitrile is combined at RT with 16.5 ml (264.5 mmol) methyl iodide and stirred for 30 min. The precipitate formed is filtered off and washed with acetonitrile.
Workup
- customThe precipitate formed
- filtrationis filtered off
- washwashed with acetonitrile
Sources & evidence
- ORD record
- ord-9e8eb94d090b4b9ebc5e1659be9e08e3
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08309542B2
Reaction notes
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