5-(4-Chlorophenyl)-2-methyl-3-furaldehyde → 1-[5-(4-Chlorophenyl)-2-methyl-3-furyl]-3-methylbutan-1-ol

HRID 1876957

Reaction equation

HRID 1876957 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]=[O:15])[CH:9]=2)=[CH:4][CH:3]=1>C([Mg]Br)C(C)C.O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([OH:15])[CH2:4][CH:5]([CH3:8])[CH3:6])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 219864715-(4-Chlorophenyl)-2-methyl-3-furaldehyde

Product 1

HCID 685126271-[5-(4-Chlorophenyl)-2-methyl-3-furyl]-3-methylbutan-1-olYield 170.5%

Reagents, catalysts & solvents 1

HCID 178420648HCID 178420648, compoundSolvent

Procedure

An operation similar to that in Example 3 (2) was performed using 5-(4-chlorophenyl)-2-methyl-3-furaldehyde (1.3 g) and 1N isobutylmagnesium bromide-tetrahydrofuran solution (10 mL) to give the title compound (1.4 g, 85%) as an oil.

Sources & evidence

ORD record
ord-a8557d7ed0d441caaabc4bed5d807053
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Linked notes

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