Methyl acetoacetate → HCID 22261473, compound

Reaction equation

Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[C:12]([O:18][CH3:19])(=[O:17])[CH2:13][C:14]([CH3:16])=O>>[F:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[O:4][C:14]([CH3:16])=[C:13]([C:12]([O:18][CH3:19])=[O:17])[CH:2]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7757Methyl acetoacetate

HCID 1202482-Chloro-4'-fluoroacetophenone

Product 1

HCID 22261473HCID 22261473, compoundYield 63%

Procedure

An operation similar to that in Example 1 (1) was performed using 2-chloro-4′-fluoroacetophenone (13.4 g) and methyl acetoacetate (8.6 g) to give the title compound (7.4 g, 63%) as a yellow crystal.

Sources & evidence

ORD record: ord-9a790d56ccf44914a3c6d2b0fd85c9dc
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309580B2

Reaction notes

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