Diethyl Ether → HCID 68439530, compound

Reaction equation

[C:1]1([C@H:7]([CH2:11]C(O)=O)[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:15][Li].C([O:19][CH2:20][CH3:21])C>>[C:1]1([C@H:7]([CH2:11][C:20](=[O:19])[CH3:21])[C:8](=[O:10])[CH3:15])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 3

HCID 3283Diethyl Ether

HCID 736146(+)-Phenylsuccinic acid

HCID 178418348HCID 178418348, compound

Product 1

HCID 68439530HCID 68439530, compound

Procedure

(S)-3-Phenylhexane-2,5-dione was synthesized from (S)-2-phenylsuccinic acid with methyllithium in diethyl ether. The analytical data apart from the optical rotation and CD corresponds to the product formed by means of PigD catalysis (FIGS. 10 and 16).