Sulfuryl chloride → HCID 68510317, compound
Reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][NH:9][CH2:8][CH2:7]2.S(Cl)([Cl:19])(=O)=O>C(O)(=O)C>[ClH:19].[Cl:1][C:5]1[C:4]([O:3][CH3:2])=[C:13]([O:14][CH3:15])[C:12]([Cl:19])=[C:11]2[C:6]=1[CH2:7][CH2:8][NH:9][CH2:10]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (200 mg, 0.870 mmol) was suspended in glacial acetic acid (5 mL) and sulphuryl chloride (154 μL, 1.92 mmol) was added slowly. The resulting mixture was stirred at room temperature for 3 hours and then evaporated to give the title compound (quant) as a yellowish mass.
Workup
- customevaporated
Sources & evidence
- ORD record
- ord-a661c6dedfb741e2bc34d2f1409ea124
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08318768B2
Reaction notes
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