2-Amino-3-bromobenzaldehyde → (2-Amino-3-bromophenyl)methanol

Reaction equation

NC1C(C=O)=CC=CC=1C(OC)=O.[NH2:14][C:15]1[C:22]([Br:23])=[CH:21][CH:20]=[CH:19][C:16]=1[CH:17]=[O:18]>>[NH2:14][C:15]1[C:22]([Br:23])=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][OH:18]

Participants

Reactant 2

HCID 100814842-Amino-3-bromobenzaldehyde

HCID 10773683Methyl 2-amino-3-formylbenzoate

Product 1

HCID 23510439(2-Amino-3-bromophenyl)methanol

Procedure

In a similar manner to the preparation of methyl 2-amino-3-formylbenzoate, 2-amino-3-bromobenzaldehyde (3.28 g, quantitatively) was obtained from (2-amino-3-bromophenyl)methanol (3.27 g).

Sources & evidence

ORD record: ord-1aa32c7f8189425891fda1d732f1c970
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06759429B2

Reaction notes

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