3-Cyanobenzoyl chloride → HCID 23508370, compound
Reaction equation
[N:1]1[N:2]=[CH:3][N:4]([NH:6][CH2:7][C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH:5]=1.[C:15]([C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20](Cl)=[O:21])#[N:16]>>[C:15]([C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([N:6]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[N:4]1[CH:3]=[N:2][N:1]=[CH:5]1)=[O:21])#[N:16]Participants
3
Procedure
The procedure of Preparation Example 34 was repeated, except that 101 mg of 4-[N-(1,2,4-triazol-4-yl)aminomethyl]phenol was used in place of 4-methoxybenzylamine, and 105 mg of 3-cyanobenzoyl chloride was used in place of 4-cyanobenzoyl chloride. The resulting crude product was purified by TLC (using a 10:1 mixture of chloroform and methanol as the developing solvent) to obtain 26 mg of 3-cyano-N-(4-hydroxybenzyl)-N-(1,2,4-triazol-4-yl)benzamide.
Workup
- customThe procedure of Preparation Example 34
- customThe resulting crude product was purified by TLC (
- additiona 10:1 mixture of chloroform and methanol as the developing solvent)