5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → 2'-Fluoro-5'-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-4-carbonitrile

HRID 188377Notes

Reaction equation

HRID 188377 reaction equation
[CH3:16][C:17]1([CH3:18])[CH2:19][O:20][B:21]([c:23]2[cH:24][cH:25][c:26]([F:37])[c:27](-[c:29]3[cH:30][cH:31][c:32]([C:35]#[N:36])[cH:33][cH:34]3)[cH:28]2)[O:22][CH2:38]1.[Cl:1][c:2]1[c:3]2[cH:4][cH:5][c:6]([C:12]([F:13])([F:14])[F:15])[n:7][c:8]2[n:9][cH:10][cH:11]1>>[c:2]1(-[c:23]2[cH:24][cH:25][c:26]([F:37])[c:27](-[c:29]3[cH:30][cH:31][c:32]([C:35]#[N:36])[cH:33][cH:34]3)[cH:28]2)[c:3]2[cH:4][cH:5][c:6]([C:12]([F:13])([F:14])[F:15])[n:7][c:8]2[n:9][cH:10][cH:11]1

Participants

3

Reactant 2

HCID 222852765-chloro-2-(trifluoromethyl)-1,8-NaphthyridineHCID 222853225'-(5,5-Dimethyl[1,3,2]dioxaborinan-2-yl)-2'-fluorobiphenyl-4-carbonitrile

Product 1

HCID 102718752'-Fluoro-5'-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-4-carbonitrile

Sources & evidence

ORD record
ord-4b4f15a21fb74820970368491fcb086d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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