2'-Aminoacetophenone → HCID 178450482, compound

HRID 1885171

Reaction equation

HRID 1885171 reaction equation
[C:1]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:5])[CH2:2][CH2:3][CH3:4].[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23](=[O:25])[CH3:24]>>[C:1]([C:6](=[CH:12][NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23](=[O:25])[CH3:24])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 110862'-AminoacetophenoneHCID 3359484Ethyl 2-butyryl-3-ethoxyacrylate

Product 1

HCID 178450482HCID 178450482, compound

Procedure

A mixture of ethyl 2-butyryl-3-ethoxyacrylate (23.5 g, 0.11 mol) and 2'-aminoacetophenone (13.5 g, 0.1 mol) was warmed on a steam bath for 10 minutes. Crystallisation from petroleum ether gave ethyl 2-butyryl-3-(2-acetylphenylamino)acrylate as a mixture of E/Z isomers (14.9 g, 49%).

Workup

  1. temperaturewas warmed on a steam bath for 10 minutes
  2. customCrystallisation from petroleum ether

Sources & evidence

ORD record
ord-18a5463c6df942f88a2780cefe61fa27
Source dataset
uspto-grants-1992_09
Patent number
US05143920

Linked notes

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