4-(2-Pyrimidinyl)-3-butynol → HCID 19876764, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][OH:11]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][OH:11]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4-(2-Pyrimidinyl)-3-butynol (1.5 g) in ethanol (40 ml) was added to pre-reduced 10% palladium on charcoal (50% aqueous paste) in ethanol (60 ml) and hydrogenated at room temperature and atmospheric pressure. The catalyst was removed by filtration through hyflo and the solvent evaporated in vacuo. The residual oil was purified by FCC. Elution with System C (19:1) and (9:1) gave the title compound as a pale yellow oil (1.32 g)
Workup
- customThe catalyst was removed by filtration through hyflo
- customthe solvent evaporated in vacuo
- customThe residual oil was purified by FCC
- washElution with System C (19:1) and (9:1)
Sources & evidence
- ORD record
- ord-1d5286cdfd2841c29128112fa4c63b42
- Source dataset
- uspto-grants-1992_09
- Patent number
- US05149698
Reaction notes
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