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MeOH tetrahydrofuran → 3-(3-Carbomethoxyphenyl)methyl-6-hydroxy-4-chromanone

HRID 1886089
Notes
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Reaction equation

HRID 1886089 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[O:15][CH2:14][C:13](=[CH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([OH:28])=[O:27])[CH:21]=1)[C:12]2=[O:29])C1C=CC=CC=1.[CH2:30]1COCC1.CO>[Pd]>[C:26]([C:22]1[CH:21]=[C:20]([CH2:19][CH:13]2[C:12](=[O:29])[C:11]3[C:16](=[CH:17][CH:18]=[C:9]([OH:8])[CH:10]=3)[O:15][CH2:14]2)[CH:25]=[CH:24][CH:23]=1)([O:28][CH3:30])=[O:27]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 21899815MeOH tetrahydrofuranHCID 545697246-Benzyloxy-3-(3-carboxyphenylmethylene)-4-chromanone

Product 1

HCID 190914643-(3-Carbomethoxyphenyl)methyl-6-hydroxy-4-chromanoneYield 63%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Conditions

Temperature
0 °C

Procedure

To a solution of 6-benzyloxy-3-)3-carboxyphenylmethylene)-4-chromanone from Step 2 (1.54 g, 3.8 mmol) in 40 ml THF/MeOH (1:3) was added 150 mg of 10% Pd/C. The mixture was hydrogenated at 40 psi for 20 hr. The mixture was filtered through celite. The filtrate was evaporated to dryness and redissolved in THF. The THF solution was cooled to 0° C. and diazomethane was added until no acid remained. Then HOAc was added. The mixture was evaporated to give an oil which was chromatographed on silica gel and eluted with 40% EtOAc/hexane to give 750 mg (63%) of the title compound.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customThe filtrate was evaporated to dryness
  3. dissolutionredissolved in THF
  4. additiondiazomethane was added until no acid
  5. additionThen HOAc was added
  6. customThe mixture was evaporated
  7. customto give an oil which
  8. customwas chromatographed on silica gel
  9. washeluted with 40% EtOAc/hexane

Sources & evidence

ORD record
ord-868f1ff3530a48ca81e46e55f6c0116d
Source dataset
uspto-grants-1992_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05149703

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes