2,5-Difluorobenzoyl chloride → HCID 71208641, compound
Reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[F:21][C:22]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:23]=1[C:24](Cl)=[O:25]>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:24](=[O:25])[C:23]3[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:22]=3[F:21])=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1Participants
3
Procedure
N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2,5-difluoro-benzamide was prepared starting from intermediate D and 2,5-difluoro-benzoyl chloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.70 (br. s., 1H) 8.28 (d, J=8.66 Hz, 1H) 8.00 (s, 1H) 7.53-7.79 (m, 5 H) 7.21-7.52 (m, 4H) 6.92 (d, J=1.81 Hz, 1H) 4.39 (d, J=5.64 Hz, 2H).
Sources & evidence
- ORD record
- ord-6807af82f885459896574f0a499d9dcf
- Source dataset
- uspto-grants-2013_08