Acetic acid, 2-hydrazinyl-, ethyl ester → 1-Methyl-3-phenyl-1H-1,2,4-triazole-5-carbaldehyde

Reaction equation

C(OC(=O)[CH2:5][N:6]1[C:10]([CH:11]=[O:12])=[N:9][C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:7]1)C.C(OC(=O)CNN)C.C1(C2OCC(=O)N=2)C=CC=CC=1>>[CH3:5][N:6]1[C:10]([CH:11]=[O:12])=[N:9][C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:7]1

Participants

Reactant 3

HCID 12509Acetic acid, 2-hydrazinyl-, ethyl ester

HCID 69174032-Phenyloxazol-4(5H)-one

HCID 86674536(5-Formyl-3-phenyl-1,2,4-triazol-1-yl)-acetic acid ethyl ester

Product 1

HCID 132241431-Methyl-3-phenyl-1H-1,2,4-triazole-5-carbaldehyde

Procedure

(5-Formyl-3-phenyl-1,2,4-triazol-1-yl)-acetic acid ethyl ester, from Hydrazino-acetic acid ethyl ester and 2-Phenyl-oxazol-4-one. H-NMR: (CDCl3) δ 10.05 (s, 1H), 8.15 (d, 2H), 7.50 (m, 3H), 5.38 (s, 2H), 4.28 (m, 2H), 1.32 (t, 3H).

Sources & evidence

ORD record: ord-2cf9a61e10294d058b4e3ad327589f6f
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501795B2

Reaction notes

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